Two middle-aged men presented with diabetic wounds to the lower extremities arising from minor incidental trauma and/or venous stasis disease; the wounds were chronic in nature and refractory to standard treatment. This short case study aims to examine the use of fragmented, activated, type I collagen in treating these wounds. The authors have used this short case study to stimulate a larger, currently ongoing study. The collagen provided and used in the treatment of these patients was in the powder-and-gel form of CellerateRx (Wound Care Innovations, LLC, Fort Lauderdale, Florida) and was provided by the manufacturer, The Hymed Group. CellerateRx is cleared by the US Food and Drug Administration to treat diabetic and nondiabetic wounds, Stages II-IV pressure ulcers, ulcers resulting from venous stasis and arterial insufficiency, traumatic wounds, and superficial and surgical wounds, including superficial and partial-thickness burns (excluding full-thickness burns). The collagen molecules found in this product are 1/100th of the size of naturally occurring collagen and present more surface area. Thus, the patient can benefit from the collagen more quickly.

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